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Abstract Secreted metabolites are an important class of bio‐process analytical technology (PAT) targets that can correlate to cell conditions. However, current strategies for measuring metabolites are limited to discrete measurements, resulting in limited understanding and ability for feedback control strategies. Herein, a continuous metabolite monitoring strategy is demonstrated using a single‐use metabolite absorbing resonant transducer (SMART) to correlate with cell growth. Polyacrylate is shown to absorb secreted metabolites from living cells containing hydroxyl and alkenyl groups such as terpenoids, that act as a plasticizer. Upon softening, the polyacrylate irreversibly conformed into engineered voids above a resonant sensor, changing the local permittivity which is interrogated, contact‐free, with a vector network analyzer. Compared to sensing using the intrinsic permittivity of cells, the SMART approach yields a 20‐fold improvement in sensitivity. Tracking growth of many cell types such as Chinese hamster ovary, HEK293, K562, HeLa, andE. colicells as well as perturbations in cell proliferation during drug screening assays are demonstrated. The sensor is benchmarked to show continuous measurement over six days, ability to track different growth conditions, selectivity to transducing active cell growth metabolites against other components found in the media, and feasibility to scale out for high throughput campaigns. 

Abstract A passive resonant sensor with kirigami patterning is presented to wirelessly report material deformation in closed systems. The sensors are fabricated from copper‐coated polyimide by etching a conductive Archimedean spiral and then laser cutting kirigami patterns. The sensor response is defined as the resonant frequency in the transmission scattering parameter signal (S₂₁), which is captured via a benchtop vector network analyzer. The sensors are tested over a 0–22 cm range of extension and show a significant shift in resonant frequency (e.g., 90 MHz shift for 10 cm stretch). Furthermore, the effect of resonator coil pitch on the extension sensor gain (MHz cm⁻¹) and linear span of the sensor is studied. The repeatability of the sensor gain is confirmed by performing hysteresis cycles. The sensors is coated with polydimethylsiloxane films to protect from electrical shorting in aqueous environments. The coated resonators are placed in a pipe to report flow rates. The sensor with 1 mm coating is found to have the largest gain (0.17 MHz⋅s mL⁻¹) and linear span (10–100 mL s⁻¹). Thus, flexible resonant sensors with kirigami‐inspired patterns can be tuned via geometric and coating considerations to wirelessly report a large range of extension lengths for potential uses in health monitoring, motion tracking, deformation detection, and soft robotics.